Motonao Osaki

T Cell Receptor Stimulation-Induced Epigenetic Changes and Foxp3 Expression Are Independent and Complementary Events Required for Treg Cell Development

Naganari Ohkura, Masahide Hamaguchi, Hiromasa Morikawa et al. · Immunity · 2012 · 726 citations · Full text

Signal Transduction, Lymphocyte Development, Immune Cell Development +11

Treg-expressed CTLA-4 depletes CD80/CD86 by trogocytosis, releasing free PD-L1 on antigen-presenting cells

Murat Tekgüç, James B. Wing, Motonao Osaki et al. · Proceedings of the National Academy of Sciences · 2021 · 400 citations · Full text

CCR8-targeted specific depletion of clonally expanded Treg cells in tumor tissues evokes potent tumor immunity with long-lasting memory

Yujiro Kidani, Wataru Nogami, Yoshiaki Yasumizu et al. · Proceedings of the National Academy of Sciences · 2022 · 186 citations · Full text

Construction of self-recognizing regulatory T cells from conventional T cells by controlling CTLA-4 and IL-2 expression

Tomoyuki Yamaguchi, Ayumi Kishi, Motonao Osaki et al. · Proceedings of the National Academy of Sciences · 2013 · 109 citations · Full text

Distinct Foxp3 enhancer elements coordinate development, maintenance, and function of regulatory T cells

Ryoji Kawakami, Yohko Kitagawa, Kelvin Y. Chen et al. · Immunity · 2021 · 74 citations · Full text

Transcriptional Regulation, Developmental Biology, Lymphocyte Development +10