High-level Coexpression of JAG1 and NOTCH1 Is Observed in Human Breast Cancer and Is Associated with Poor Overall Survival

Michael Reedijk, Silvia Odorcic, Lynn Chang, +5

Cancer Research

Tumor BiologyBreast OncologyOncologyPoor Overall SurvivalHigh-level Coexpression +12

The Steel/W transduction pathway: kit autophosphorylation and its association with a unique subset of cytoplasmic signaling proteins is induced by the Steel factor.

Robert Rottapel, Michael Reedijk, DE Williams, +4

Molecular and Cellular Biology

GeneticsCellular PhysiologyTranscriptional RegulationSteel FactorSignaling Pathway +15

Metformin in early breast cancer: a prospective window of opportunity neoadjuvant study

Saroj Niraula, Ryan J.O. Dowling, Marguerite Ennis, +9

Breast Cancer Research and Treatment

Breast OncologyOncologyEarly Breast CancerOpportunity Neoadjuvant StudyCancer Management +6

Tyr721 regulates specific binding of the CSF-1 receptor kinase insert to PI 3′-kinase SH2 domains: a model for SH2-mediated receptor-target interactions.

Michael Reedijk, X. Johné Liu, Peter van der Geer, +4

The EMBO Journal

High-level JAG1 mRNA and protein predict poor outcome in breast cancer

Brendan C. Dickson, Anna Marie Mulligan, Hui Zhang, +4

Modern Pathology

Radiation OncologyBreast OncologyEngineeringPoor OutcomeMedicine +12

A Multicentered, Randomized, Controlled Trial Comparing Radioguided Seed Localization to Standard Wire Localization for Nonpalpable, Invasive and in situ Breast Carcinomas

Peter Lovrics, Charlie H. Goldsmith, Nicole Hodgson, +5

Annals of Surgical Oncology

Breast OncologyRadiation TherapySitu Breast CarcinomasMedicineCancer Detection +9

SH2 Domains of the p85α Subunit of Phosphatidylinositol 3-Kinase Regulate Binding to Growth Factor Receptors

C Jane McGlade, Christine Ellis, Michael Reedijk, +9

Molecular and Cellular Biology

Molecular RegulationComplex FormationSh2 DomainsCellular PhysiologySignaling Pathway +18

Cyclin D1 is a direct target of JAG1-mediated Notch signaling in breast cancer

Brenda Cohen, Mamiko Shimizu, Julia Izrailit, +5

Breast Cancer Research and Treatment

Cancer ResearchBreast OncologySignal TransductionJag1-mediated Notch SignalingSignaling Pathway +9

Interactions of phosphatidylinositol kinase, GTPase-activating protein (GAP), and GAP-associated proteins with the colony-stimulating factor 1 receptor.

Michael Reedijk, X. Johné Liu, Tony Pawson

Molecular and Cellular Biology

Molecular RegulationImmunologyCell DeathGap-associated ProteinsCellular Physiology +22

JAG1 expression is associated with a basal phenotype and recurrence in lymph node-negative breast cancer

Michael Reedijk, Dushanthi Pinnaduwage, Brendan C. Dickson, +6

Breast Cancer Research and Treatment

Breast OncologyMedicineBasal PhenotypeJag1 ExpressionBreast Cancer +9