Fresh frozen plasma versus prothrombin complex concentrate in patients with intracranial haemorrhage related to vitamin K antagonists (INCH): a randomised trial

Thorsten Steiner, Sven Poli, Martin Griebe, +14

The Lancet Neurology

ThrombosisIntracranial HaemorrhageMedicineRandomised TrialHematology +13

Oncolytic H-1 Parvovirus Shows Safety and Signs of Immunogenic Activity in a First Phase I/IIa Glioblastoma Trial

Karsten Geletneky, Jacek Hajda, Assia L. Angelova, +24

Molecular Therapy

Phase I/IIa study of intratumoral/intracerebral or intravenous/intracerebral administration of Parvovirus H-1 (ParvOryx) in patients with progressive primary or recurrent glioblastoma multiforme: ParvOryx01 protocol

Karsten Geletneky, Johannes Huesing, Jean Rommelaere, +7

BMC Cancer

Garlic extract induces intestinal P-glycoprotein, but exhibits no effect on intestinal and hepatic CYP3A4 in humans

Jacek Hajda, Katharina Rentsch, Christoph Gubler, +3

European Journal of Pharmaceutical Sciences

InflammationAllergyMedicineLiver PhysiologyHerb-drug Interaction +5

A non-controlled, single arm, open label, phase II study of intravenous and intratumoral administration of ParvOryx in patients with metastatic, inoperable pancreatic cancer: ParvOryx02 protocol

Jacek Hajda, Monika Lehmann, Ottheinz Krebs, +16

BMC Cancer

Vorinostat in refractory soft tissue sarcomas – Results of a multi-centre phase II trial of the German Soft Tissue Sarcoma and Bone Tumour Working Group (AIO)

Thomas Schmitt, Regine Mayer‐Steinacker, Frank Mayer, +14

European Journal of Cancer

Surgical OncologyMedicineSurgeryOncologyRadiation Oncology

Phase 2 Trial of Oncolytic H-1 Parvovirus Therapy Shows Safety and Signs of Immune System Activation in Patients With Metastatic Pancreatic Ductal Adenocarcinoma

Jacek Hajda, Barbara Leuchs, Assia L. Angelova, +19

Clinical Cancer Research

Sequential First‐Pass Metabolism of Nortilidine: The Active Metabolite of the Synthetic Opioid Drug Tilidine

Jacek Hajda, E. Jähnchen, Svein Øie, +1

The Journal of Clinical Pharmacology

Bioavailability, biodistribution, and CNS toxicity of clinical-grade parvovirus H1 after intravenous and intracerebral injection in rats.

Karsten Geletneky, Anne Laure Leoni, Gabriele Pohlmeyer-Esch, +9

PubMed

NeurovirologyAutonomous Parvovirus H1MedicineViral PathogenesisImmunology +12

Pathology, organ distribution, and immune response after single and repeated intravenous injection of rats with clinical-grade parvovirus H1.

Karsten Geletneky, Anne Laure Leoni, Gabriele Pohlmeyer-Esch, +11

PubMed

Parvovirus H1HepatologyRodent-borne DiseasesIntravenous InjectionLiver Physiology +13