Functional identity of hypothalamic melanocortin neurons depends on Tbx3

Carmelo Quarta, Alexandre Fisette, Yanjun Xu, +28

Nature Metabolism

Functional IdentityNeurophysiologyPhysiologyNeuroendocrine MechanismHypothalamic Peptide +6

Bardet-Biedl syndrome proteins regulate intracellular signaling and neuronal function in patient-specific iPSC-derived neurons

Liheng Wang, Yang Liu, George Stratigopoulos, +16

Journal of Clinical Investigation

Metabolic DisorderPrimary CiliumSynaptic SignalingInsulin SignalingSocial Sciences +20

Cis-regulatory architecture of human ESC-derived hypothalamic neuron differentiation aids in variant-to-gene mapping of relevant complex traits

Matthew C. Pahl, Claudia A. Doege, Kenyaita M. Hodge, +20

Nature Communications

Ciliary gene RPGRIP1L is required for hypothalamic arcuate neuron development

Liheng Wang, Alain J. De Solís, Yossef Goffer, +19

JCI Insight

Characterization of Rare Variants in MC4R in African American and Latino Children With Severe Early-Onset Obesity

Maria Caterina De Rosa, Alessandra Chesi, Shana E. McCormack, +11

The Journal of Clinical Endocrinology & Metabolism

Osteopontin drives neuroinflammation and cell loss in MAPT-N279K frontotemporal dementia patient neurons

Osama Al‐Dalahmah, Matti Lam, Julie J. McInvale, +33

Cell stem cell

Cell LossOxidative StressNeuroinflammationAlzheimer's DiseaseDegenerative Pathology +14

Binding of polyunsaturated fatty acids to LXR<i>α</i> and modulation of SREBP‐1 interaction with a specific SCD1 promoter element

Mariella Caputo, Maria Caterina De Rosa, Tania Rescigno, +5

Cell Biochemistry and Function

DMSO increases efficiency of genome editing at two non-coding loci

George Stratigopoulos, Maria Caterina De Rosa, Charles A. LeDuc, +2

PLoS ONE

Crispr/cas9 EfficiencyNatural SciencesGeneticsGenomic MechanismMolecular Biology +13

Identification of Genes Selectively Regulated in Human Hepatoma Cells by Treatment With Dyslipidemic Sera and PUFAs

Maria Caterina De Rosa, Mariella Caputo, Hylde Zirpoli, +6

Journal of Cellular Physiology

Gene expression atlas of energy balance brain regions

Maria Caterina De Rosa, Hannah J. Glover, George Stratigopoulos, +8

JCI Insight

NeurogenomicsMetabolic DisorderEnergy BalanceGeneticsGene Expression Atlas +17