Structure of the WW domain of a kinase-associated protein complexed with a proline-rich peptide

María J. Macias, Marko Hyvönen, Elena Baraldi, +4

Nature

Proline-rich PeptideProtein FunctionSignal TransductionBiochemistryKinase-associated Protein +6

Specific interactions between the syntrophin PDZ domain and voltage-gated sodium channels

Johan Schultz, Ulrich Hoffmuüller, Gerd Krause, +5

Nature Structural Biology

Syntrophin Pdz DomainHyperpolarization (Biology)NeurophysiologySpecific InteractionsSynaptic Transmission +9

Targeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination

Nina Gustafsson, Katarina Färnegårdh, Nadilly Bonagas, +18

Nature Communications

Identification of novel quinazoline derivatives as potent antiplasmodial agents

Anne Bouchut, Dante Rotili, Christine Pierrot, +14

European Journal of Medicinal Chemistry

Medicinal ChemistryNovel Quinazoline DerivativesBioorganic ChemistryAntiparasitic AgentMedicine +6

Site-Selective Screening by NMR Spectroscopy with Labeled Amino Acid Pairs

Johan Weigelt, Maria van Dongen, J. Uppenberg, +2

Journal of the American Chemical Society

Amino Acid XAmino Acid YBiochemistryStructural BioinformaticsNatural Sciences +11

Structure-Based Screening As Applied to Human FABP4:  A Highly Efficient Alternative to HTS for Hit Generation

Maria J. P. van Dongen, J. Uppenberg, Stefan Svensson, +4

Journal of the American Chemical Society

First-in-class oral small molecule inhibitor of the tyrosine kinase ROR1 (KAN0439834) induced significant apoptosis of chronic lymphocytic leukemia cells

Mohammad Hojjat‐Farsangi, Amir Hossein Daneshmanesh, Abdul Salam Khan, +17

Leukemia

Significant ApoptosisMedicineApoptosisReceptor Tyrosine KinaseCell Death +6

Mechanochemical study of conformational transitions and melting of Li‐, Na‐, K‐, and CsDNA fibers in ethanol–water solutions

A. Rupprecht, Jure Piškur, Johan Schultz, +3

Biopolymers

EngineeringMolecular BiologyFiber SpinningFiber ScienceSoft Matter +16

A receptor tyrosine kinase ROR1 inhibitor (KAN0439834) induced significant apoptosis of pancreatic cells which was enhanced by erlotinib and ibrutinib

Amir Hossein Daneshmanesh, Mohammad Hojjat‐Farsangi, Amineh Ghaderi, +9

PLoS ONE

Inhibition of Histone Demethylases LSD1 and UTX Regulates ERα Signaling in Breast Cancer

Rosaria Benedetti, Carmela Dell’Aversana, Tommaso De Marchi, +19

Cancers

Histone ModificationsEpigenetic ChangeCancer BiologyLsd1 InhibitorEpigenetics +23