Next-generation characterization of the Cancer Cell Line Encyclopedia

Mahmoud Ghandi, Franklin W. Huang, Judit Jané‐Valbuena, +65

Nature

Tumor HeterogeneityMedicineCancer GenomicsNext-generation CharacterizationCancer Biology +4

Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate

Abhishek A. Chakraborty, Tuomas Laukka, Matti Myllykoski, +16

Science

Defining HLA-II Ligand Processing and Binding Rules with Mass Spectrometry Enhances Cancer Epitope Prediction

Jennifer G. Abelin, Dewi Harjanto, Matthew Malloy, +23

Immunity

HistocompatibilityTumor BiologyHla-ii Ligand ProcessingOncologyCancer Epitope Prediction +12

High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program

David P. Labbé, Giorgia Zadra, Meng Yang, +31

Nature Communications

Reduced-representation Phosphosignatures Measured by Quantitative Targeted MS Capture Cellular States and Enable Large-scale Comparison of Drug-induced Phenotypes

Jennifer G. Abelin, Jinal Patel, Xiaodong Lü, +17

Molecular & Cellular Proteomics

A Library of Phosphoproteomic and Chromatin Signatures for Characterizing Cellular Responses to Drug Perturbations

Lev Litichevskiy, Ryan Peckner, Jennifer G. Abelin, +31

Cell Systems

Building the Connectivity Map of epigenetics: Chromatin profiling by quantitative targeted mass spectrometry

Amanda L. Creech, Jordan E. Taylor, Verena Maier, +8

Methods

ChromatinFunctional GenomicsChromatin RemodelingMedicineEpigenetic Change +9

Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma

Pratiti Bandopadhayay, Federica Piccioni, Ryan O’Rourke, +53

Nature Communications

Molecular NeuroscienceDevelopmental BiologyCell RegulationMedicineCell Interaction +6

Functional Proteomic Analysis of Repressive Histone Methyltransferase Complexes Reveals ZNF518B as a G9A Regulator*

Verena Maier, Caitlin M. Feeney, Jordan E. Taylor, +11

Molecular & Cellular Proteomics

HIF activation causes synthetic lethality between the <i>VHL</i> tumor suppressor and the <i>EZH1</i> histone methyltransferase

Abhishek A. Chakraborty, Eijiro Nakamura, Jun Qi, +15

Science Translational Medicine