HIV-1 Capsid-Cyclophilin Interactions Determine Nuclear Import Pathway, Integration Targeting and Replication Efficiency

Torsten Schaller, Karen E. Ocwieja, Jane Rasaiyaah, +12

PLoS Pathogens

Virus StructureReplication EfficiencyViral ReplicationIntegration TargetingHuman Retrovirus +12

HIV-1 evades innate immune recognition through specific cofactor recruitment

Jane Rasaiyaah, Choon Ping Tan, Adam J. Fletcher, +8

Nature

Human RetrovirusImmunologyAntiviral ResponseVirologyInnate Immunity +4

Host Cofactors and Pharmacologic Ligands Share an Essential Interface in HIV-1 Capsid That Is Lost upon Disassembly

Amanda J. Price, David A. Jacques, William A. McEwan, +6

PLoS Pathogens

Host CofactorsProtein AssemblyImmunologyMolecular BiologyViral Structural Protein +16

CPSF6 Defines a Conserved Capsid Interface that Modulates HIV-1 Replication

Amanda J. Price, Adam J. Fletcher, Torsten Schaller, +6

PLoS Pathogens

Virus StructureViral ReplicationSignal TransductionHuman RetrovirusCpsf6 Binding +12

Sequential ubiquitination and deubiquitination enzymes synchronize the dual sensor and effector functions of TRIM21

Adam J. Fletcher, Donna L. Mallery, Ruth Watkinson, +2

Proceedings of the National Academy of Sciences

Tripartite MotifImmunologySignal RecognitionMolecular BiologyInnate Immunity +16

Trivalent RING Assembly on Retroviral Capsids Activates TRIM5 Ubiquitination and Innate Immune Signaling

Adam J. Fletcher, Marina Vaysburd, Sarah Maslen, +4

Cell Host & Microbe

<scp>TRIM</scp> 5α requires Ube2W to anchor Lys63‐linked ubiquitin chains and restrict reverse transcription

Adam J. Fletcher, Devin E. Christensen, Chad Nelson, +5

The EMBO Journal

Cellular IP6 Levels Limit HIV Production while Viruses that Cannot Efficiently Package IP6 Are Attenuated for Infection and Replication

Donna L. Mallery, K. M. Rifat Faysal, Alex B. Kleinpeter, +8

Cell Reports

Intracellular antibody signalling is regulated by phosphorylation of the Fc receptor TRIM21

Claire F. Dickson, Adam J. Fletcher, Marina Vaysburd, +12

eLife

Innate Immune SystemImmunologyImmune RegulationImmunologic MechanismInnate Immunity +24

Deubiquitinating enzyme amino acid profiling reveals a class of ubiquitin esterases

Virginia De Cesare, Daniel Carbajo, Peter D. Mabbitt, +5

Proceedings of the National Academy of Sciences

EngineeringAldo-keto ReductaseMolecular BiologyChemical BiologyEnzymatic Modification +17