Ikushi Nakamura

The catalytic carboxyester hydrolysis by a new zinc(II) complex with an alcohol-pendant cyclen (1-(2-hydroxyethyl)-1,4,7,10-tetraazacyclododecane): A novel model for indirect activation of the serine nucleophile by zinc(II) in zinc enzymes

Tohru Koike, Satoko Kajitani, Ikushi Nakamura et al. · Journal of the American Chemical Society · 1995 · 184 citations

Zinc Enzymes, Indirect Activation, Catalytic Carboxyester Hydrolysis +14

Carboxyester Hydrolysis Promoted by a New Zinc(II) Macrocyclic Triamine Complex with an Alkoxide Pendant: A Model Study for the Serine Alkoxide Nucleophile in Zinc Enzymes

Eiichi Kimura, Ikushi Nakamura, Tohru Koike et al. · Journal of the American Chemical Society · 1994 · 127 citations

Bioorganic Chemistry, Engineering, Chemical Analysis +17

The first anionic sulfonamide-binding zinc(II) complexes with a macrocyclic triamine: chemical verification of the sulfonamide inhibition of carbonic anhydrase

Tohru Koike, Eiichi Kimura, Ikushi Nakamura et al. · Journal of the American Chemical Society · 1992 · 126 citations

Chemical Analysis, Altmetric Attention Score, Organic Chemistry +17

Discovery of IRL 3461: a novel and potent endothelin antagonist with balanced ETA/ETB affinity

Junichi Sakaki, Toshiki Murata, Yoko Yuumoto et al. · Bioorganic & Medicinal Chemistry Letters · 1998 · 13 citations · Full text

Medicinal Chemistry, Irl 3461, Biochemistry +9