Structural organization of brain-derived mammalian prions examined by hydrogen-deuterium exchange

Vytautas Smirnovas, Gerald S. Baron, Danielle K. Offerdahl, +3

Nature Structural & Molecular Biology

Molecular NeuroscienceBiochemistryHydrogen-deuterium ExchangeNeuroanatomyNatural Sciences +7

Insulin forms amyloid in a strain‐dependent manner: An FT‐IR spectroscopic study

Wojciech Dzwolak, Vytautas Smirnovas, Ralf Jansen, +1

Protein Science

Insulin FormsBiochemistryEthanol Triggers GrowthProtein FoldingStrain‐dependent Manner +13

Ethanol-Perturbed Amyloidogenic Self-Assembly of Insulin:  Looking for Origins of Amyloid Strains

Wojciech Dzwolak, Stefan Grudzielanek, Vytautas Smirnovas, +6

Biochemistry

Solvation-assisted Pressure Tuning of Insulin Fibrillation: From Novel Aggregation Pathways to Biotechnological Applications

Stefan Grudzielanek, Vytautas Smirnovas, Roland Winter

Journal of Molecular Biology

EngineeringBioengineering ModelInsulin ManagementDiabetesBiochemical Engineering +13

Discovery and Characterization of Novel Selective Inhibitors of Carbonic Anhydrase IX

Virginija Dudutienė, Jurgita Matulienė, David D. Timm, +30

Journal of Medicinal Chemistry

Combinatorial ChemistryBioorganic ChemistryOrganic ChemistryChemical BiologyPharmaceutical Chemistry +15

Interplay between Hydrogen Bonding and Macromolecular Architecture Leading to Unusual Phase Behavior in Thermosensitive Microgels

Martina Keerl, Vytautas Smirnovas, Roland Winter, +1

Angewandte Chemie International Edition

EngineeringDepressed StatePolyelectrolyte GelChemistrySoft Matter +16

Cytotoxicity of Insulin within its Self-assembly and Amyloidogenic Pathways

Stefan Grudzielanek, Aleksandra Velkova, Anuj Shukla, +5

Journal of Molecular Biology

BiochemistryDiabetesAmyloidogenic PathwaysProtein MisfoldingInsulin Delivery +1

Distinct Structures of Scrapie Prion Protein (PrPSc)-seeded Versus Spontaneous Recombinant Prion Protein Fibrils Revealed by Hydrogen/Deuterium Exchange

Vytautas Smirnovas, Jae-Il Kim, Xiaojun Lu, +3

Journal of Biological Chemistry

BiochemistryProtein AssemblyProtein FoldingScrapie Prion ProteinHydrogen/deuterium Exchange +11

Finke–Watzky Two-Step Nucleation–Autocatalysis Model of S100A9 Amyloid Formation: Protein Misfolding as “Nucleation” Event

Igor A. Iashchishyn, Darius Šulskis, Mai Nguyen Ngoc, +2

ACS Chemical Neuroscience

Protein ChemistryProtein AssemblyBiochemistryProtein FoldingS100a9 Amyloid Formation +11

Copolymer Microgels from Mono- and Disubstituted Acrylamides: Phase Behavior and Hydrogen Bonds

Martina Keerl, Vytautas Smirnovas, Roland Winter, +1

Macromolecules

EngineeringResponsive PolymersPolyelectrolyte GelBiomedical EngineeringChemistry +18