Potent inhibitors of human LAT1 (SLC7A5) transporter based on dithiazole and dithiazine compounds for development of anticancer drugs

Lara Napolitano, Mariafrancesca Scalise, Maria Koyioni, +10

Biochemical Pharmacology

Medicinal ChemistryHuman Lat1Pharmaceutical ScienceMedicinePharmacological Agent +8

Role of the<scp>GM</scp>1 ganglioside oligosaccharide portion in the TrkA‐dependent neurite sprouting in neuroblastoma cells

Elena Chiricozzi, Diego Yuri Pomè, Margherita Maggioni, +6

Journal of Neurochemistry

Novel insights into the transport mechanism of the human amino acid transporter LAT1 (SLC7A5). Probing critical residues for substrate translocation

Lara Napolitano, Michele Galluccio, Mariafrancesca Scalise, +4

Biochimica et Biophysica Acta (BBA) - General Subjects

Protein FunctionBiochemistryNatural SciencesMembrane TransportMolecular Biology +7

Predicting estrogen receptor binding of chemicals using a suite of in silico methods – Complementary approaches of (Q)SAR, molecular docking and molecular dynamics

J. Cotterill, Luca Palazzolo, C. Ridgway, +5

Toxicology and Applied Pharmacology

Drug TargetEngineeringEstrogen ReceptorPharmacotherapyComputational Chemistry +20

Enzymatic reduction of acetophenone derivatives with a benzil reductase from Pichia glucozyma (KRED1-Pglu): electronic and steric effects on activity and enantioselectivity

Martina Letizia Contente, Immacolata Serra, Luca Palazzolo, +7

Organic & Biomolecular Chemistry

Bioorganic ChemistryEngineeringAldo-keto ReductaseAcetophenone DerivativesBenzil Reductase +19

Rabphilin-3A as a novel target to reverse α-synuclein-induced synaptic loss in Parkinson’s disease

Elena Ferrari, Diego Scheggia, Elisa Zianni, +11

Pharmacological Research

Synaptic Transmissionα-Synuclein-induced Synaptic LossSynaptic SignalingSocial SciencesNeurobiology Of Disease +21

Propiconazole is an activator of AHR and causes concentration additive effects with an established AHR ligand

Constanze Knebel, Juliane Kebben, Ivano Eberini, +8

Archives of Toxicology

BiochemistryMedicineNatural SciencesConcentration Additive EffectsMechanism Of Action +5

SLC6A14, a Pivotal Actor on Cancer Stage: When Function Meets Structure

Luca Palazzolo, Chiara Paravicini, Tommaso Laurenzi, +8

SLAS DISCOVERY

Set-Up and Validation of a High Throughput Screening Method for Human Monoacylglycerol Lipase (MAGL) Based on a New Red Fluorescent Probe

Matteo Miceli, Silvana Casati, Roberta Ottria, +5

Molecules

Lipid AnalysisBioorganic ChemistryChemical BiologyPharmaceutical ChemistryMedicinal Chemistry +15

Design, synthesis, molecular modelling and in vitro cytotoxicity analysis of novel carbamate derivatives as inhibitors of Monoacylglycerol lipase

Simone Lauria, Cristiana Perrotta, Silvana Casati, +6

Bioorganic & Medicinal Chemistry

Lipid PreparationBiochemistryNovel Carbamate DerivativesMedicineMonoacylglycerol Lipase +3