Augmentation of Immune Checkpoint Cancer Immunotherapy with IL18

Zhifeng Ma, Wen Li, Shinichi Yoshiya, +9

Clinical Cancer Research

Interleukin-18–deficient mice develop dyslipidemia resulting in nonalcoholic fatty liver disease and steatohepatitis

Kyosuke Yamanishi, Seishi Maeda, Sachi Kuwahara‐Otani, +12

Translational research

InflammationMetabolic SyndromeMetabolic Associated SteatohepatitisHepatologyMetabolic Associated Steatotic Liver Disease +12

Frontline Science: IL-18 primes murine NK cells for proliferation by promoting protein synthesis, survival, and autophagy

Yosif El‐Darawish, Wen Li, Kyosuke Yamanishi, +7

Journal of Leukocyte Biology

The impacts of elevated autism spectrum disorder traits on clinical and psychosocial features and long-term treatment outcome in adult patients with obsessive-compulsive disorder

Hironori Mito, Naomi Matsuura, Keiitiro Mukai, +6

Comprehensive Psychiatry

Long-term Treatment OutcomePsychiatrySyndromic AutismAdult PatientsObsessive-compulsive Disorder +10

Elevated levels of interleukin-18 are associated with several indices of general and visceral adiposity and insulin resistance in women with polycystic ovary syndrome

Plamena Kabakchieva, Antoaneta Gateva, Tsvetelina Velikova, +4

Archives of Endocrinology and Metabolism

Interleukin-18-deficient mice develop hippocampal abnormalities related to possible depressive-like behaviors

Kyosuke Yamanishi, Nobutaka Doe, Keiichiro Mukai, +16

Neuroscience

PsychoneuroimmunologyPsychopathologyStress HormonePsychiatryMedicine +10

Hepatocyte Nuclear Factor 4 Alpha Is a Key Factor Related to Depression and Physiological Homeostasis in the Mouse Brain

Kyosuke Yamanishi, Nobutaka Doe, Miho Sumida, +8

PLoS ONE

Neurochemical BiomarkersPhysiological HomeostasisGene Expression ProfilingSerotonin MetabolismChronic Mild Stress +17

Chymase inhibition improves vascular dysfunction and survival in stroke-prone spontaneously hypertensive rats

Shinji Takai, Denan Jin, Hong Chen, +7

Journal of Hypertension

Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment

Hideo Hagihara, Hirotaka Shoji, Satoko Hattori, +128

eLife

NeuropsychologyBrain FunctionNeuropsychiatric DisordersBrain DevelopmentLactate Levels +22

Analysis of genes causing hypertension and stroke in spontaneously hypertensive rats: Gene expression profiles in the brain

Momoko Yoshida, Yuko Watanabe, Kyosuke Yamanishi, +9

International Journal of Molecular Medicine

HypertensionNeurogenomicsBrain DevelopmentGeneticsGenetic Epidemiology +26