Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring

Yu Shi, Weina Gao, Nikki K. Lytle, +35

Nature

Tumor BiologyDrug TargetingPancreatic CancerLif-mediated Paracrine InteractionMedicine +6

Epigenetic changes induced by adenosine augmentation therapy prevent epileptogenesis

Rebecca L. Williams-Karnesky, Ursula S. Sandau, Theresa A. Lusardi, +5

Journal of Clinical Investigation

ChromatinDna Methylation HomeostasisEpigenetic ChangeDna MethylationEpigenomics +7

A Multiscale Map of the Stem Cell State in Pancreatic Adenocarcinoma

Nikki K. Lytle, L. Paige Ferguson, Nirakar Rajbhandari, +30

Cell

Lineage PlasticityCell LineagePancreatic CancerMedicineStem Cell Research +8

Image-based detection and targeting of therapy resistance in pancreatic adenocarcinoma

Raymond G. Fox, Nikki K. Lytle, Dawn V. Jaquish, +22

Nature

EngineeringOncologic ImagingPancreatic CancerMedicineBiomedical Imaging +9

Epigenetic and Transcriptomic Profiling of Mammary Gland Development and Tumor Models Disclose Regulators of Cell State Plasticity

Christopher Dravis, Chi‐Yeh Chung, Nikki K. Lytle, +5

Cancer Cell

Breast OncologyTranscriptomic ProfilingEpigenetic ChangeEpigeneticsMammary Gland Development +14

Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas

Jelena Todoric, Laura Antonucci, Giuseppe Di, +14

Cancer Cell

Pancreatic CancerMedicinePathologyCancer BiologyCell Biology +2

Ubiquitin-conjugating enzyme Ubc13 controls breast cancer metastasis through a TAK1-p38 MAP kinase cascade

Xuefeng Wu, Weizhou Zhang, Joan Font-Burgada, +14

Proceedings of the National Academy of Sciences

Breast Cancer MetastasisTumor BiologyBreast OncologyMetastatic SpreadBca Metastasis +12

Single-Cell Transcriptomics Reveals a Conserved Metaplasia Program in Pancreatic Injury

Zhibo Ma, Nikki K. Lytle, Bob Chen, +21

Gastroenterology

Functional GenomicsPancreatic CancerSingle Cell SequencingMedicinePathology +6

Adenosine augmentation ameliorates psychotic and cognitive endophenotypes of schizophrenia

Hai‐Ying Shen, Philipp Singer, Nikki K. Lytle, +6

Journal of Clinical Investigation

NeuropsychologyAdenosine KinasePsychopharmacologySocial SciencesAdenosine Signaling +14

Tuft Cells Inhibit Pancreatic Tumorigenesis in Mice by Producing Prostaglandin D2

Kathleen E. DelGiorno, Chi-Yeh Chung, Vera Vavinskaya, +26

Gastroenterology

Cancer ResearchPancreatic CancerMedicineImmunologyCell Death +6