3CL Protease Inhibitors with an Electrophilic Arylketone Moiety as Anti-SARS-CoV-2 Agents

Sho Konno, Kiyotaka Kobayashi, Miki Senda, +18

Journal of Medicinal Chemistry

Influenza A Virus Infection Triggers Pyroptosis and Apoptosis of Respiratory Epithelial Cells through the Type I Interferon Signaling Pathway in a Mutually Exclusive Manner

SangJoon Lee, Mikako Hirohama, Masayuki Noguchi, +2

Journal of Virology

Spectomycin B1 as a Novel SUMOylation Inhibitor That Directly Binds to SUMO E2

Mikako Hirohama, Ashutosh Kumar, Isao Fukuda, +13

ACS Chemical Biology

Breast OncologyMolecular BiologySumo E2Spectomycin B1 TreatmentSpectomycin B1 +15

Inhibition of protein SUMOylation by davidiin, an ellagitannin from Davidia involucrata

Misao Takemoto, Yumi Kawamura, Mikako Hirohama, +10

The Journal of Antibiotics

BiochemistryDavidia InvolucrataMechanism Of ActionProtein SumoylationPharmacology

Influenza restriction factor MxA functions as inflammasome sensor in the respiratory epithelium

SangJoon Lee, Akari Ishitsuka, Masayuki Noguchi, +7

Science Immunology

Influenza Virus Induces Cholesterol-Enriched Endocytic Recycling Compartments for Budozone Formation via Cell Cycle-Independent Centrosome Maturation

Atsushi Kawaguchi, Mikako Hirohama, Yoshimi Harada, +2

PLoS Pathogens

Viral ReplicationViral PathogenesisMolecular BiologyCytoskeletonViral Structural Protein +14

Identification of Sumoylation Activating Enzyme 1 Inhibitors by Structure-Based Virtual Screening

Ashutosh Kumar, Akihiro Ito, Mikako Hirohama, +2

Journal of Chemical Information and Modeling

Drug TargetMolecular BiologyChemical BiologyEnzymatic ModificationStructure-based Virtual Screening +21

Identification of new SUMO activating enzyme 1 inhibitors using virtual screening and scaffold hopping

Ashutosh Kumar, Akihiro Ito, Mikako Hirohama, +2

Bioorganic & Medicinal Chemistry Letters

Virtual ScreeningScaffold HoppingDrug TargetBiochemistryNatural Sciences +7

Identification of quinazolinyloxy biaryl urea as a new class of SUMO activating enzyme 1 inhibitors

Ashutosh Kumar, Akihiro Ito, Mikako Hirohama, +2

Bioorganic & Medicinal Chemistry Letters

Bioorganic ChemistryAldo-keto ReductaseBiochemistryMedicineNatural Sciences +8

Inhibition of Influenza Virus Infection by Lentinus edodes Mycelia Extract Through Its Direct Action and Immunopotentiating Activity

Takahiro Kuroki, SangJoon Lee, Mikako Hirohama, +5

Frontiers in Microbiology