Microenvironmental pH Is a Key Factor for Exosome Traffic in Tumor Cells

Isabella Parolini, Cristina Federici, Carla Raggi, +11

Journal of Biological Chemistry

Saposin C mutations in Gaucher disease patients resulting in lysosomal lipid accumulation, saposin C deficiency, but normal prosaposin processing and sorting

Anna Maria Vaccaro, Marialetizia Motta, Massimo Tatti, +6

Human Molecular Genetics

GeneticsSaposin C MutationsGlycobiologyImmunologyPathology +18

pH-dependent Conformational Properties of Saposins and Their Interactions with Phospholipid Membranes

Anna Maria Vaccaro, Fiorella Ciaffoni, Massimo Tatti, +4

Journal of Biological Chemistry

Structural Analysis of Saposin C and B

Anna Maria Vaccaro, Rosa Salvioli, Alessandra Barca, +7

Journal of Biological Chemistry

Reduced cathepsins B and D cause impaired autophagic degradation that can be almost completely restored by overexpression of these two proteases in Sap C-deficient fibroblasts

Massimo Tatti, Marialetizia Motta, Sabrina Di Bartolomeo, +4

Human Molecular Genetics

MitophagyImmunologyCell DeathPathologySap C +21

Effect of Saposins A and C on the Enzymatic Hydrolysis of Liposomal Glucosylceramide

Anna Maria Vaccaro, Massimo Tatti, Fiorella Ciaffoni, +3

Journal of Biological Chemistry

Proteinlipid InteractionSmall Unilamellar VesiclesGlycobiologyLarge Unilamellar VesiclesSap C +16

Cathepsin-mediated regulation of autophagy in saposin C deficiency

Massimo Tatti, Marialetizia Motta, Sabrina Di Bartolomeo, +2

Autophagy

MitophagyImmunologyPathologyCell DeathCellular Physiology +18

Saposin C induces pH‐dependent destabilization and fusion of phosphatidylserine‐containing vesicles

Anna Maria Vaccaro, Massimo Tatti, Fiorella Ciaffoni, +3

FEBS Letters

Proteinlipid InteractionGlycobiologyCytoskeletonSap CPs Vesicles +17

Function of saposin C in the reconstitution of glucosylceramidase by phosphatidylserine liposomes

Anna Maria Vaccaro, Massimo Tatti, Fiorella Ciaffoni, +3

FEBS Letters

Enzyme StimulationProteinlipid InteractionSignal TransductionGlycosylationBiochemistry +13

Clinical, biochemical and molecular characterization of prosaposin deficiency

Marialetizia Motta, Massimo Tatti, Francesca Furlan, +8

Clinical Genetics

Psap Deficiency DiagnosisGeneticsPathologyPsap GeneDisease Gene Identification +14