Direct binding of polymeric GBP1 to LPS disrupts bacterial cell envelope functions

Miriam Kutsch, Linda Sistemich, Cammie F. Lesser, +3

The EMBO Journal

Nucleotide-dependent farnesyl switch orchestrates polymerization and membrane binding of human guanylate-binding protein 1

Sergii Shydlovskyi, Anke Y. Zienert, Semra İnce, +11

Proceedings of the National Academy of Sciences

LPS-aggregating proteins GBP1 and GBP2 are each sufficient to enhance caspase-4 activation both in cellulo and in vitro

Mary S Dickinson, Miriam Kutsch, Linda Sistemich, +6

Proceedings of the National Academy of Sciences

The bacterial effector GarD shields Chlamydia trachomatis inclusions from RNF213-mediated ubiquitylation and destruction

Stephen C. Walsh, Jeffrey R. Reitano, Mary S Dickinson, +10

Cell Host & Microbe

Chlamydia Trachomatis InclusionsRnf213-mediated UbiquitylationPathogenesisMolecular BiologyMicrobiology +4

Dynamin‐related Irgm proteins modulate LPS‐induced caspase‐11 activation and septic shock

Ryan Finethy, Jacob Dockterman, Miriam Kutsch, +10

EMBO Reports

InflammationSignal TransductionMolecular PhysiologyDisease PathophysiologyInnate Immune System +13

The human guanylate‐binding proteins <scp>hGBP</scp>‐1 and <scp>hGBP</scp>‐5 cycle between monomers and dimers only

Semra İnce, Miriam Kutsch, Sergii Shydlovskyi, +1

FEBS Journal

The Molecular Mechanism of Polymer Formation of Farnesylated Human Guanylate-binding Protein 1

Linda Sistemich, Miriam Kutsch, Benjamin Hämisch, +6

Journal of Molecular Biology

A Rapidly Evolving Polybasic Motif Modulates Bacterial Detection by Guanylate Binding Proteins

Kristin Kohler, Miriam Kutsch, Anthony S. Piro, +3

mBio

Structural requirements for membrane binding of human guanylate‐binding protein 1

Linda Sistemich, Lyubomir Dimitrov Stanchev, Miriam Kutsch, +3

FEBS Journal

Catalytic activity of human guanylate‐binding protein 1 coupled to the release of structural restraints imposed by the C‐terminal domain

Semra İnce, Ping Zhang, Miriam Kutsch, +3

FEBS Journal