M. Silvina Frech

p21 with a phenylalanine 28—-leucine mutation reacts normally with the GTPase activating protein GAP but nevertheless has transforming properties.

Jochen Reinstein, Ilme Schlichting, M. Silvina Frech et al. · Journal of Biological Chemistry · 1991 · 104 citations · Full text

Molecular Regulation, Protein Gap, Bound Gdp/gtp +16

Deregulated estrogen receptor alpha expression in mammary epithelial cells of transgenic mice results in the development of ductal carcinoma in situ.

M. Silvina Frech, Ewa D Halama, Maddalena T. Tilli et al. · PubMed · 2005 · 92 citations · Full text

Breast Oncology, Gynecology, Pathology +19

The inhibition of the GTPase activating protein-Ha-ras interaction by acidic lipids is due to physical association of the C-terminal domain of the GTPase activating protein with micellar structures.

Jürgen Serth, Alfred Lautwein, M. Silvina Frech et al. · The EMBO Journal · 1991 · 86 citations · Full text

Proteinlipid Interaction, Signal Transduction, Biochemistry +12

Deregulated Estrogen Receptor α Expression in Mammary Epithelial Cells of Transgenic Mice Results in the Development of Ductal Carcinoma <i>In situ</i>

M. Silvina Frech, Ewa D Halama, Maddalena T. Tilli et al. · Cancer Research · 2005 · 80 citations · Full text

Breast Oncology, Gynecology, Mammary Gland Development +20

Introduction of Estrogen Receptor-α into the tTA/TAg Conditional Mouse Model Precipitates the Development of Estrogen-Responsive Mammary Adenocarcinoma

Maddalena T. Tilli, M. Silvina Frech, Mary Ellen Steed et al. · American Journal Of Pathology · 2003 · 51 citations · Full text

Breast Oncology, Estrogen Receptor-α, Hormonal Receptor +12