p21 with a phenylalanine 28—-leucine mutation reacts normally with the GTPase activating protein GAP but nevertheless has transforming properties.

Jochen Reinstein, Ilme Schlichting, M. Silvina Frech, +2

Journal of Biological Chemistry

Molecular RegulationProtein GapBound Gdp/gtpMolecular BiologyGdp Bound Form +14

Deregulated estrogen receptor alpha expression in mammary epithelial cells of transgenic mice results in the development of ductal carcinoma in situ.

M. Silvina Frech, Ewa D Halama, Maddalena T. Tilli, +5

PubMed

Breast OncologyGynecologyPathologyMammary Gland DevelopmentTumor Biology +17

The inhibition of the GTPase activating protein-Ha-ras interaction by acidic lipids is due to physical association of the C-terminal domain of the GTPase activating protein with micellar structures.

Jürgen Serth, Alfred Lautwein, M. Silvina Frech, +2

The EMBO Journal

Proteinlipid InteractionSignal TransductionBiochemistryG Protein-coupled ReceptorCell Signaling +10

Deregulated Estrogen Receptor α Expression in Mammary Epithelial Cells of Transgenic Mice Results in the Development of Ductal Carcinoma <i>In situ</i>

M. Silvina Frech, Ewa D Halama, Maddalena T. Tilli, +5

Cancer Research

Breast OncologyGynecologyMammary Gland DevelopmentTumor BiologyEndocrine Oncology +18

Introduction of Estrogen Receptor-α into the tTA/TAg Conditional Mouse Model Precipitates the Development of Estrogen-Responsive Mammary Adenocarcinoma

Maddalena T. Tilli, M. Silvina Frech, Mary Ellen Steed, +4

American Journal Of Pathology

Breast OncologyEstrogen Receptor-αHormonal ReceptorMammary GlandGynecology +10

Effects of ERα overexpression on female reproduction in mice

Dragana Tomic, M. Silvina Frech, Janice K. Babus, +4

Reproductive Toxicology

FertilityFemale InfertilityFemale ReproductionGynecologyFemale Reproductive System +8

Methoxychlor Induces Atresia of Antral Follicles in ERα-Overexpressing Mice

Dragana Tomic, M. Silvina Frech, Janice K. Babus, +4

Toxicological Sciences

FertilityLipid PeroxidationFemale Reproductive FunctionTransgenic Mouse ModelReproductive Biology +20

Translational cancer research comes of age in Latin America

Andrea S. Llera, Osvaldo L. Podhajcer, M. Breitenbach, +9

Science Translational Medicine

Loss of cyclin D1 in concert with deregulated estrogen receptor α expression induces DNA damage response activation and interrupts mammary gland morphogenesis

M. Silvina Frech, Kathleen M. Torre, Gertraud W. Robinson, +1

Oncogene

Cyclin D1Hormonal ReceptorMammary GlandGynecologyFemale Reproductive Function +6

Loss of protein phosphatase 2A expression correlates with phosphorylation of DP-1 and reversal of dysplasia through differentiation in a conditional mouse model of cancer progression.

Maddalena T. Tilli, Shawnté L. Hudgins, M. Silvina Frech, +3

PubMed

PathologyCancer BiologyTumor BiologySignaling PathwayCell Regulation +16