Determination of melagatran, a novel, direct thrombin inhibitor, in human plasma and urine by liquid chromatography–mass spectrometry

Marita Larsson, Ulrika Logren, Martin Ahnoff, +4

Journal of Chromatography B

Medicinal ChemistryPharmaceutical ScienceLiquid Chromatography–mass SpectrometryBiochemistryMedicine +10

Enantioselective determination of felodipine in human plasma by chiral normal-phase liquid chromatography and electrospray ionisation mass spectrometry

Bo Lindmark, Martin Ahnoff, Bengt‐Arne Persson

Journal of Pharmaceutical and Biomedical Analysis

Gas ChromatographyMedicineMass SpectrometryHuman PlasmaEnantioselective Determination +8

Design and Optimization of Pyrazinecarboxamide-Based Inhibitors of Diacylglycerol Acyltransferase 1 (DGAT1) Leading to a Clinical Candidate Dimethylpyrazinecarboxamide Phenylcyclohexylacetic Acid (AZD7687)

Jonas G. Barlind, Udo Bauer, Alan M. Birch, +19

Journal of Medicinal Chemistry

Pharmaceutical ScienceCandidate DrugPyrazinecarboxamide Dgat1 InhibitorsPharmacotherapyNew Series +15

Accelerated drug discovery by rapid candidate drug identification

Fredrik Bergström, Bo Lindmark

Drug Discovery Today

Medicinal ChemistryDrug TargetHit IdentificationMedicineComputational Biology +5

Inhibition of AMP Deaminase Activity Does Not Improve Glucose Control in Rodent Models of Insulin Resistance or Diabetes

Therése Admyre, Lena Amrot-Fors, Maria Andersson, +11

Chemistry & Biology

Insulin ResistanceDiabetes ManagementBiochemistryMedicineGlucose Control +10

Enantioselective pharmacokinetics of the enantiomers of clevidipine following intravenous infusion of the racemate in essential hypertensive patients

Hans Ericsson, Jonas Schwieler, Bo Lindmark, +3

Chirality

HypertensionHeart FailurePharmacotherapyIndividual PharmacokineticsPhysiologically-based Pharmacokinetic Modeling +14

Time dependent analysis of assay comparability: a novel approach to understand intra- and inter-site variability over time

Susanne Winiwarter, Brian Middleton, Barry Jones, +5

Journal of Computer-Aided Molecular Design

EngineeringUncertainty QuantificationAssay ComparabilityBioanalysisMedicine +13

Human hepatocytes and cytochrome P450‐selective inhibitors predict variability in human drug exposure more accurately than human recombinant <scp>P450s</scp>

Bo Lindmark, Anna Lundahl, Kajsa P. Kanebratt, +2

British Journal of Pharmacology

Identification of Mineralocorticoid Receptor Modulators with Low Impact on Electrolyte Homeostasis but Maintained Organ Protection

Kenneth L. Granberg, Zhong-Qing Yuan, Bo Lindmark, +26

Journal of Medicinal Chemistry

Electrolyte DisorderHeart FailureHomeostatic MechanismPharmacotherapyMedicinal Chemistry +21

Structure‐Based Drug Design of Mineralocorticoid Receptor Antagonists to Explore Oxosteroid Receptor Selectivity

Anneli Nordqvist, Gavin O’Mahony, Maria Fridén‐Saxin, +18

ChemMedChem