Laxmikant Gadhe

α-Synuclein aggregation nucleates through liquid–liquid phase separation

Soumik Ray, Nitu Singh, Rakesh Kumar et al. · Nature Chemistry · 2020 · 841 citations

Liquid–liquid Phase Separation, Protein Phase Separation, Phase Separation +3

Intermolecular interactions underlie protein/peptide phase separation irrespective of sequence and structure at crowded milieu

Manisha Poudyal, Komal Patel, Laxmikant Gadhe et al. · Nature Communications · 2023 · 143 citations · Full text

Glycosaminoglycans have variable effects on α-synuclein aggregation and differentially affect the activities of the resulting amyloid fibrils

Surabhi Mehra, Dhiman Ghosh, Rakesh Kumar et al. · Journal of Biological Chemistry · 2018 · 73 citations · Full text

Comparison of Kinetics, Toxicity, Oligomer Formation, and Membrane Binding Capacity of α-Synuclein Familial Mutations at the A53 Site, Including the Newly Discovered A53V Mutation

Ganesh M. Mohite, Rakesh Kumar, Rajlaxmi Panigrahi et al. · Biochemistry · 2018 · 54 citations

Oligomer Formation, Molecular Biology, Neurochemical Biomarkers +19

α-Synuclein Aggregation Intermediates form Fibril Polymorphs with Distinct Prion-like Properties

Surabhi Mehra, Sahil Ahlawat, Harish Kumar et al. · Journal of Molecular Biology · 2022 · 27 citations

α-Synuclein Aggregation Intermediates, Protein Folding, Molecular Biology +4