Design, Synthesis, and Biological Evaluation of a Series of Benzo[<i>de</i>][1,7]naphthyridin-7(8<i>H</i>)-ones Bearing a Functionalized Longer Chain Appendage as Novel PARP1 Inhibitors

Na Ye, Chuan-Huizi Chen, Tiantian Chen, +10

Journal of Medicinal Chemistry

Parp1 EnzymeMedicinal ChemistryBioorganic ChemistryBiochemistryNatural Sciences +12

Poly(ADP-ribose)polymerase (PARP) inhibition and anticancer activity of simmiparib, a new inhibitor undergoing clinical trials

Bo Yuan, Na Ye, Shan-shan Song, +19

Cancer Letters

MedicinePathologyAnticancer ActivityPharmacotherapyAnti-cancer Agent +4

Design, Synthesis, and Pharmacological Evaluation of Biaryl-Containing PD-1/PD-L1 Interaction Inhibitors Bearing a Unique Difluoromethyleneoxy Linkage

Zilan Song, Bo Liu, Xia Peng, +7

Journal of Medicinal Chemistry

Discovery of Novel 2,4-Diarylaminopyrimidine Analogues (DAAPalogues) Showing Potent Inhibitory Activities against Both Wild-type and Mutant ALK Kinases

Zilan Song, Yanhong Yang, Zhiqing Liu, +8

Journal of Medicinal Chemistry

Alk-addicted CellsDrug TargetPharmacotherapyChemical BiologyPharmaceutical Chemistry +14

Thioparib inhibits homologous recombination repair, activates the <scp>type I IFN</scp> response, and overcomes olaparib resistance

Li‐Min Wang, Pingyuan Wang, X. T. Chen, +20

EMBO Molecular Medicine

Structure–Activity Relationship Study of Amidobenzimidazole Analogues Leading to Potent and Systemically Administrable Stimulator of Interferon Gene (STING) Agonists

Zilan Song, Xiyuan Wang, Yan Zhang, +8

Journal of Medicinal Chemistry

Design, synthesis and biological evaluation of a series of novel 2-benzamide-4-(6-oxy-N-methyl-1-naphthamide)-pyridine derivatives as potent fibroblast growth factor receptor (FGFR) inhibitors

Manman Wei, Peng Xia, Li Xing, +6

European Journal of Medicinal Chemistry

Medicinal ChemistryBiochemistryMedicineNatural SciencesPharmacological Agent +6

Novel 2,4-Diarylaminopyrimidine Analogues (DAAPalogues) Showing Potent c-Met/ALK Multikinase Inhibitory Activities

Zhiqing Liu, Jing Ai, Peng Xia, +9

ACS Medicinal Chemistry Letters

Drug TargetPharmacotherapyChemical BiologyPharmaceutical ChemistryMedicinal Chemistry +15

Design, synthesis and pharmacological evaluation of ALK and Hsp90 dual inhibitors bearing resorcinol and 2,4-diaminopyrimidine motifs

Kaijun Geng, Hong‐Chun Liu, Zilan Song, +7

European Journal of Medicinal Chemistry

Hsp90 Dual InhibitorsCombinatorial ChemistryMedicinal ChemistryDrug TargetBiochemistry +10

A novel tricyclic BTK inhibitor suppresses B cell responses and osteoclastic bone erosion in rheumatoid arthritis

Yuting Liu, Huihua Ding, Zemin Lin, +15

Acta Pharmacologica Sinica

InflammationRheumatologyRheumatoid DisorderB Cell ResponsesAnti-inflammatory +9