Sergey Brezgin

Orthologous CRISPR/Cas9 systems for specific and efficient degradation of covalently closed circular DNA of hepatitis B virus

Dmitry Kostyushev, Sergey Brezgin, Anastasiya Kostyusheva et al. · Cellular and Molecular Life Sciences · 2019 · 83 citations · Full text

Engineering, Viral Hepatitis, Dna Replication +11

Suppressing the NHEJ pathway by DNA-PKcs inhibitor NU7026 prevents degradation of HBV cccDNA cleaved by CRISPR/Cas9

Dmitry Kostyushev, Anastasiya Kostyusheva, Sergey Brezgin et al. · Scientific Reports · 2019 · 53 citations · Full text

ATM and ATR Expression Potentiates HBV Replication and Contributes to Reactivation of HBV Infection upon DNA Damage

Anastasiya Kostyusheva, Sergey Brezgin, Ekaterina Bayurova et al. · Viruses · 2019 · 27 citations · Full text

Genome Instability, Viral Replication, Dna Damage +15

Depleting hepatitis B virus relaxed circular DNA is necessary for resolution of infection by CRISPR-Cas9

Dmitry Kostyushev, Anastasiya Kostyusheva, Sergey Brezgin et al. · Molecular Therapy — Nucleic Acids · 2023 · 27 citations · Full text

Small Molecular Inhibitors of DNA Double Strand Break Repair Pathways Increase the ANTI-HBV Activity of CRISPR/Cas9

Anastasiya Kostyusheva, Dmitry Kostyushev, Sergey Brezgin et al. · Molecular Biology · 2019 · 22 citations