It has previously been demonstrated that phenanthroline-based ligands used to make gold metallotherapuetics have the ability to exhibit cytotoxicity when not coordinated to the metal center. In an effort to help assess the mechanism by which these ligands may cause tumor cell death, iron binding and removal experiments have been considered. The close linkage between cell proliferation and intracellular iron concentrations suggest that iron deprivation strategies may be a mechanism involved in inhibiting tumor cell growth. With the creation of iron (III) phen complexes, the iron binding abilities of three polypyridal ligands [1,10-phenanthroline (phen), 2,9-dimethyl-1, 10-phenanthroline (^methylphen), and 2,9-di-sec-butyl-1, 10-phenanthroline ( ^sec-butylphen)] can be tested via a competition reaction with a known iron chelator. Therefore, iron (III) complexes possessing all three ligands were synthesized. Initial mass spectrometric and infrared absorption data indicate that iron (III) tetrachloride complex ions with protonated phen ligands (^RphenH⁺) were formed: [phenH][FeCl₄], [^methylphenH][FeCl₄], [ ^sec-butylphenH][FeCl₄]. UV-Vis spectroscopy was used to monitor the stability of the complex ions, and it was found that the ^sec-butylpheniron complex was more stable than the phen and ^methylphen analogues. This was based on the observation that free ligand was observed immediately upon the addition of EDTA to the [phenH][FeCl₄] and [^methylphenH] [FeCl₄] complex ions.

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