STUDIES ON VALIDAMYCINS, NEW ANTIBIOTICS. VI

Abstract

In this communication we wish to describe the structure elucidation of validamine, la, and hydroxyvalidamine, IIa1}, which were obtained from validamycin A and validamycin B, respectively, by hydrogenolysis, followed by acid hydrolysis. This communication also discusses the determination of the structures of validatol, Ilia, and deoxyvalidatol IV1}, which were obtained from both validamycins A and B by hydrogenolysis. Validamine was crystallized as its monohydrochloride (C7HloNO4-HCl*; m.p. 229-