PubMed · 1989 · 17 citations · 0 references
MedicineNephrologyPathologyAutoimmunityImmunopathologyRenal PathologyAutoimmune Kidney DiseaseGlomerular DiseasesImmune-mediated Renal DiseaseRenal DiseaseRenal ImmunopathologyThyroid DisordersImmune Complex GlomerulonephritisImmune Complex NephritisImmune Complex-mediated NephritisImmune-mediated NephritisImmunopathology Of Renal DiseaseRenal Biopsy DiagnosisRenal Biopsy FindingsRenal Immune Complex Deposition
We describe a patient with Graves' disease in whom marked proteinuria, microhematuria and hypoalbuminemia were associated. Renal biopsy demonstrated electrondense deposits in the capillary basement membrane, a finding consistent with immune complex glomerulonephritis. Indirect immunofluorescent examination with rabbit antihuman thyroglobulin indicated that these electron-dense deposits were thyroid antigen-mediated immune complexes.