Pim-1 protein kinase is nuclear in Burkitt's lymphoma: nuclear localization is necessary for its biologic effects.

Yurij Ionov, Xuan Le, Brian Tunquist, John Sweetenham, Traci Sachs, John Ryder, Thomas R. Johnson, Andrew S. Kraft

PubMed · 2003 · 48 citations · 0 references

Abstract

The nuclear location of Pim-1 is essential for its regulation of the levels of HDM2 protein, and possibly for additional biological activities of this protein kinase.