A Double-Blind Study in Healthy Volunteers to Assess the Effects on Sleep of Pregabalin Compared with Alprazolam and Placebo

Abstract

Pregabalin appears to have an effect on sleep and sleep architecture that distinguishes it from benzodiazepines. Enhancement of slow-wave sleep is intriguing, since reductions in slow-wave sleep have frequently been reported in fibromyalgia and general anxiety disorder.