2006 · 49 citations · 0 references
PharmacyPharmaceutical AnalysisPharmacologyBioavailabilityDrug DiscoveryPharmaceutical FormulationCrystal ChemistryCrystal Habit AnalysisDrug DissolutionDrug SolubilitySolution ChemistrySolvation TheoryCrystal HabitCrystal Habit ObservationCrystal Habit PolymorphismCrystallinity Effects On SolubilityDrug Crystal FormDrug Solubility ScreeningSolubilitySolubility Determination
Solubility, polymorphism, crystallinity, and crystal habit of acetaminophen and racemic (±)-ibuprofen were determined by initial screening of 23 solvents for scale-up. Solubility curves were constructed, and solubility at 25 °C was plotted against the dielectric constants of various solvent as a fingerprint for solute identification. The totalform space for acetaminophen and racemic (±)-ibuprofen were calculated to be 222 and 257, respectively. Various crystal habits and sizes for ibuprofen and acetaminophen were observed.