Journal of Chemotherapy · 2004 · 12 citations · 0 references
MedicineOncologyPharmacologyChemotherapyGastrointestinal OncologyMedical OncologyChemotherapy Toxicity ManagementColorectal CancerHigh-dose ChemotherapyLiver MetastasisMetastatic Disease ManagementToxicity ManagementHigh-dose Chemotherapy AdministrationIntra-arterial Chemotherapy AdministrationLiver Metastases ManagementLiver Metastases TreatmentLiver Metastasis Response AssessmentLiver Toxicity AssessmentMetastatic Liver Disease Treatment
A multicenter randomized study comparing high dose of mitomycin and epirubicin given as hepatic intra-arterial chemotherapy (HIAC) combined with caval chemofiltration (CF) versus low doses of the same drugs in unresectable liver metastases from colorectal cancer showed a significant improvement in the survival rate of the 20 patients treated with high dose compared to the 22 patients treated with low doses with a 1 year survival of 69% vs 39%. The median survival was 17 vs 11 months and the responses were 65% vs 33%. Toxicity was colangitis in 50% of patients considered. The extrahepatic progression was similar in the two groups (7/20 vs 8/22).