Concepedia

Inside the Neutrophil Phagosome: Oxidants, Myeloperoxidase, and Bacterial Killing

Mark B. Hampton, Anthony J. Kettle, Christine C. Winterbourn

Blood · 1998 · 1.4K citations · 146 references

DOI

Concepts

Abstract

IN THE 1880s Elie Metchnikoff observed specialized phagocytic cells ingesting bacteria, and recognized the importance of phagocytosis as a defense mechanism in multicellular organisms.[1][1] Neutrophils are one of the professional phagocytes in humans. They ingest bacteria into intracellular

References

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The Metabolic Basis of Inherited Disease.

Annals of Internal Medicine · 1988 · 7.8K citations

, , +13

Biological Defense Mechanisms. THE PRODUCTION BY LEUKOCYTES OF SUPEROXIDE, A POTENTIAL BACTERICIDAL AGENT

Bernard Babior, Ruby S. Kipnes, John T. Curnutte · Journal of Clinical Investigation · 1973 · 2.9K citations · Full text

, , +17

Inflammation. Basic principles and clinical correlates

Biomedicine & Pharmacotherapy · 1989 · 2.4K citations · Full text

, , +14

Macrophage phagocytosis of aging neutrophils in inflammation. Programmed cell death in the neutrophil leads to its recognition by macrophages.

John Savill, A H Wyllie, J E Henson et al. · Journal of Clinical Investigation · 1989 · 1.5K citations · Full text

, , +17

The Biochemical Basis of Phagocytosis

Anthony J. Sbarra, Manfred L. Karnovsky · Journal of Biological Chemistry · 1959 · 1.2K citations · Full text

, , +9