OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information) · 1981 · 10 citations · 0 references
MedicineOncologyToxicologyCancer PreventionCarcinogenesisEnvironmental ToxicologyCarcinogenic MechanismsCarcinogenicity AssessmentChemical CarcinogenesisEnvironmental CarcinogenesisEnvironmental CarcinogensVolatile Organic CompoundsCancer Risk AssessmentCarcinogenicity Of SolventsChemical Carcinogen ExposureMechanisms Of CarcinogenicityMechanisms Of Chemical CarcinogenesisSkin CarcinogenesisTumor Incidence AnalysisVolatile Organic Compounds Exposure
The tumorigenicity to mouse skin of volatile components of roofing asphalts and coal tar pitches was investigated. Male CD-1 and C3H/H3J-mice were exposed to 25 milligrams per application of ashpalt volatiles or 1.5 to 4.2 milligrams per application of pitch preparations. Treatment was twice weekly for an 18 month period with two temperatures of generation of volatile materials and exposure or lack of exposure to simulated sunlight. The C3H strain of mice was more sensitive to the tumorigenic activity, while simulated sunlight had an inhibitory effect on the rate of appearance of tumors but not on the final tumor incidence. The higher temperature of preparation of the asphalt volatiles resulted in greater tumorigenic activity. The authors conclude that the asphalt volatiles were almost as tumorigenic and carcinogenic to C3H-mice as the pitch volatiles.