Inhibition of tau hyperphosphorylation and beta amyloid production in rat brain by oral administration of atorvastatin.

Abstract

Hypercholesteremia could induce tau hyperphosphorylation and Abeta production in rat brain. Atorvastatin could inhibit tau hyperphosphorylation and decrease Abeta generation. It may play a protective role in the patho-process of hypercholesteremia-induced neurodegeneration in the brain.