Recent military experience with malaria chemoprophylaxis

Abstract

These studies confirm that doxycycline is very effective in preventing falciparum malaria and, for the first time, also suggest that doxycycline used in combination with small doses of primaquine may prevent (not only suppress) vivax malaria. If further studies confirm these findings, the use of such a drug combination would reduce the incidence of both vivax and falciparum malaria in returning travellers. For individuals with a high risk of exposure to malaria, it would also forestall the need to take the bothersome primaquine eradication course.