Concepedia

Inhibition of human immunodeficiency virus type 1 replication by human interferons alpha, beta and gamma.

Janet K. Yamamoto, M L Kruzel, Harry Louie, J A Georgiades

PubMed · 1993 · 14 citations · 0 references

Concepts

Life SciencesMicrobiologyMolecular BiologyImmunology Of Infectious DiseasesMolecular VirologyVirologyAntiviral ImmunityAntiviral PharmacologyHost-virus InteractionsInterferon ResponsesViral InfectionsViral ReplicationAntiviral Interferon ResponsesInhibition Of Interferon ResponsesInterferon ProductionInterferon Response To Viral InfectionType I Interferon Responses

Abstract

The effect of various preparations of human interferon (HuIFN) upon human immunodeficiency virus (HIV-1) replication in cell lines and primary cultures of peripheral blood lymphocytes (PBL) was investigated. Natural interferon alpha (nHuIFN-alpha) exhibited a much higher inhibitory effect upon HIV-1 replication than did recombinant HuIFN-alpha (rHuIFN-alpha).