PubMed · 1991 · 12 citations · 0 references
PharmacyPharmaceuticsPharmacologyBioavailabilityControlled Release FormulationsDrug DeliveryControlled Release Oral Dosage FormsDissolution ApparatusDrug Delivery SystemsDrug DissolutionDrug Release From Dosage FormsDrug Release KineticsDissolution-induced Drug ReleaseDissolution-mediated Drug ReleaseDrug Release MechanismsDrug Release ModelingIn Vivo StudiesOsmotic Pump TabletsPolynomial RegressionRelease Profile Characterization
The drug release of salbutamol from a controlled release (osmotic pump) tablet was determined in vitro by four different dissolution apparatuses. From published in vivo data, percent of drug absorbed and percent of drug released in vivo were estimated. The highest correlation was obtained between percentage released in vitro versus percentage released in vivo using polynomial regression.