The APACHE III Prognostic System

APACHE II-A Severity of Disease Classification System

William A. Knaus, Elizabeth A. Draper, Douglas P. Wagner et al. · Critical Care Medicine · 1986 · 13.4K citations

Health Professions, Biostatistics, Clinical Classification Systems +12

Flexible regression models with cubic splines

Sylvain Durrleman, Richard Simon · Statistics in Medicine · 1989 · 2.7K citations

Public Health, Biostatistics, Epidemiologic Methods +16

Treatment of Gram-Negative Bacteremia and Septic Shock with HA-1A Human Monoclonal Antibody against Endotoxin

Elizabeth Ziegler, Charles J. Fisher, Charles L. Sprung et al. · New England Journal of Medicine · 1991 · 1.6K citations · Full text

Veterinary Medicine, Immunology, Pharmacotherapy +17

An Evaluation of Outcome from Intensive Care in Major Medical Centers

William A. Knaus · Annals of Internal Medicine · 1986 · 1.2K citations

Medicine, Health Administration, Critical Care Medicine +13

Sepsis syndrome: a valid clinical entity. Methylprednisolone Severe Sepsis Study Group.

R C Bone, Charles J. Fisher, T. P. Clemmer et al. · PubMed · 1989 · 699 citations

Veterinary Medicine, Infectious Diseases, Internal Medicine +13