Chronic Respiratory Disease · 2015 · 40 citations · 26 references
Public HealthInjury PreventionInjury SurveillanceRisk AssessmentSleep MedicineInjury EpidemiologyInjury RiskSleep-disordered BreathingSleep-related Breathing DisordersTraffic Injury PreventionTraffic SafetyAttributable Fraction EstimationDriver Risk AssessmentEpidemiological MeasurementRoad Traffic CrashesRoad Traffic InjuriesRoad Traffic Injury EpidemiologyRoad Traffic Injury RiskSleep Apnea Syndrome
The association between motor vehicle accidents (MVAs) and obstructive sleep apnea syndrome (OSAS) has always been quantified as risk of MVAs for individual drivers with OSAS. We evaluated the expected injured patients per year attributable to OSAS-dependent MVAs in a general population. By combining OSAS prevalence and OSAS-dependent MVAs odds ratio, we assessed the population attributable fraction (PAF), an epidemiological tool that can be used to quantify the proportion of road traffic injuries (RTIs) attributable to OSAS. For an apnea hypopnea index >5, the weighed median and combined average of OSAS prevalence were 4.4 (95% confidence interval (CI): 3.7-7.5) and 4.7 (95% CI: 4.2-5.2), respectively; values of risk of OSAS-dependent MVAs were 2.83 (95% CI: 2.72-3.08) and 2.52 (95% CI: 2.07-3.08), respectively. The PAF showed weighed median and combined average values of 6.6 (95% CI: 4.3-9.8) and 7.3% (95% CI: 6.0-13.5), respectively. Our results show that about 7% of RTIs for a population of male drivers involved in MVAs are attributable to OSAS. This value can be used to assess the potential impact, on the reduction of incidence of the motor vehicle injuries, of prevention programs aimed at reducing the number of subjects with an undiagnosed and/or untreated OSAS.
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The Occurrence of Sleep-Disordered Breathing among Middle-Aged Adults
Terry Young, Mari Palta, Jerome A. Dempsey et al. · New England Journal of Medicine · 1993 · 10.2K citations · Full text
Pathogenesis of upper airway occlusion during sleep
John E. Remmers, William J. deGroot, Eberhardt K. Sauerland et al. · Journal of Applied Physiology · 1978 · 1.9K citations