Toxic epidermal caused by lamotrigine.

Abstract

Toxic epidermal necrolysis (TEN) is a potentially fatal adverse mucocutaneous drug reaction. Simple maculopapular rashes occur commonly with lamotrigrine. Although rare, serious mucocutaneous reactions such as TEN can occur soon after commencement of treatment with lamotrigine, or after a dose increase in patients already established on treatment. The risk can be minimised by commencing at a low dose, avoiding rapid increases in dosage, and avoiding concomitant use of sodium valproate.