MedicineDevelopmental BiologyGynecologyReproductive BiologyReproductive EndocrinologyReproductive GeneticsDisorders Of Sex DevelopmentGonadal DisordersGonadal Sex DifferentiationReproductive DisordersSexual DifferentiationTesticular DisordersDisorders Of Sexual DifferentiationMale Reproductive Tract PathologySexual Development DisruptionSry Gene Abnormalities
A female French bulldog was presented with an enlarged clitoris. Abdominal surgery revealed a normal uterus and gonads resembling testes. Histologically, the gonads contained seminiferous tubules. The karyotype was XX, and the SRY gene was not detected. A diagnosis of XX male, SRY negative disorder of sexual development was made.
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R-spondin1 is essential in sex determination, skin differentiation and malignancy
P. Parma, Orietta Radi, Valérie Vidal et al. · Nature Genetics · 2006 · 772 citations
Sox9 induces testis development in XX transgenic mice
Valérie Vidal, Marie‐Christine Chaboissier, Dirk G. de Rooij et al. · Nature Genetics · 2001 · 665 citations
A 11.7-kb deletion triggers intersexuality and polledness in goats
Éric Pailhoux, B. Vigier, Stéphane Chaffaux et al. · Nature Genetics · 2001 · 350 citations