The Effects of Modafinil and Cognitive Behavior Therapy on Sleep Continuity in Patients with Primary Insomnia

Abstract

These data suggest that modafinil may be used to diminish the negative side effects of CBT (increased daytime sleepiness) and may increase subject compliance with therapy. Whether enhanced daytime function mediates the change in adherence and whether reduced sleepiness and enhanced compliance translate to less patient attrition in the clinical setting remain to be evaluated.