Concepedia

Recurrence of acute leukemia in donor cells after bone marrow transplantation: documentation by in situ DNA hybridization.

M Mouratidou, Damianos Sotiropoulos, K Deremitzaki, D H Spathas, A. V. Hoffbrand, H. G. Prentice, K Papanastasiou, S Tsakanikas, Panayiotis Tsaftaridis, Marina Stamatelou

PubMed · 1993 · 23 citations · 0 references

Concepts

MedicineHematologyOncologyMolecular OncologyStem Cell TransplantationAllogeneic Stem Cell TransplantationDonor Lymphocyte InfusionHematopoietic Stem Cell TransplantationIn Situ HybridizationAcute LeukemiasAcute Promyelocytic LeukemiaDna Hybridization AssaysDna Hybridization DetectionDna In Situ HybridizationLeukemia CytogeneticsRelapsed Acute Myeloid LeukemiaTransplantation For Hematologic Malignancies

Abstract

Donor cell leukemia after BMT has been documented in a small number of cases mainly by cytogenetic studies. We describe a case of leukemia relapse in a 16-year-old girl 1 year after BMT from her histocompatible brother. Relapse in donor cells was initially suspected on the basis of cytogenetic analysis and confirmed by DNA in situ hybridization in blast cells using a Y chromosome-specific probe.