Analgesic property of different extracts of Curcuma longa (Linn.): an experimental study in animals.

Abstract

Different extracts of Curcuma longa , code named as PC/CL/SWP05, CL/111107506 and PT/0606188, each at three doses 100, 200 and 400 mg/kg were evaluated for their analgesic activity using different animal models of analgesia. PT/0606188 exhibited significant analgesic activity in the tail flick test at 400 mg/kg one hour after administration. CL/111107506 exhibited significant analgesic activity in the tail withdrawal test, one hour after administration at a dose of 100 mg/kg. All the three extracts significantly reduced the number of writhes in the acetic acid test except for PT/0606188 at a dose of 100 mg/kg. PC/CL/SWP05 demonstrated only peripheral analgesic activity while CL/ 111107506 and PT/0606188 demonstrated both central and peripheral analgesic activities.