Prevalence of the Sickle Cell Trait in Adults of Charleston County, SC

Abstract

A survey of Negro residents of Charleston County, SC, in 1960 to 1964 revealed a high prevalence of the sickle cell trait at 14.6%. The prevalence did not differ between the sexes, nor did it vary significantly with age groups, (ages 35 to 74). Thus, there is no suggestion based on these cross-sectional data of selective mortality in adults associated with possession of the sickle cell trait. The prevalence of the sickle cell trait was significantly higher in the occupational groups of lowest socioeconomic status. Among individuals of low socioeconomic status, the prevalence was higher in residents of rural areas of Charleston County. Probable explanations for these findings include selective malarial mortality in childhood, cultural, and physical isolation, assortative mating, and endogamy.