Formulation and in-vitro evaluation of dextrin matrix tablet of Ibuprofen for colon specific drug delivery.

Abstract

The objective of the present study is to develop colon targeted drug delivery system by using dextrin (polysaccharide) as a carrier for ibuprofen. Matrix tablets containing various excipients and dextrin were prepared by wet granulation technique using different binder systems. The matrix tablets were evaluated by different IPQC tests, content uniformity and in vitro drug release study. Drug release profile was evaluated in simulated gastric, intestinal fluid and simulated colonic fluid. Best formulation was decided on the basis drug release profile in simulated gastric and intestinal fluid. The matrix tablet containing dextrin as a carrier and ethyl cellulose as binder was found to be suitable for targeting ibuprofen for local action in the colon as compare to other matrix tablets containing different binders because of fewer amounts (8-11%) of drug release in the simulated gastric and intestinal fluid. Matrix tablets containing dextrin released 95-98% of ibuprofen in simulated colonic fluid with 4% human fecal matter solution. Tablets containing dextrin showed no change in physical appearance and dissolution profile upon storage at 40 degrees C/75% relative humidity for three months. The results of in-vitro study indicate that matrix tablets containing dextrin as carrier and ethyl cellulose as binder are most suitable to deliver the drug specifically in colonic region as compare to matrix tablets of dextrin with other binder systems.