Regulation of the Kynurenine Pathway by IFN-γ in Murine Cloned Macrophages and Microglial Cells

Relationship between interferon‐γ, indoleamine 2,3‐dioxygenase, and tryptophan catabolism

Milton W. Taylor, Gen‐Sheng Feng · The FASEB Journal · 1991 · 1.1K citations

Life Sciences, Immunology, Infectious Diseases +15

Mechanism of interferon-gamma action. Characterization of indoleamine 2,3-dioxygenase in cultured human cells induced by interferon-gamma and evaluation of the enzyme-mediated tryptophan degradation in its anticellular activity.

Osamu Takikawa, Takashi Kuroiwa, Fumio Yamazaki et al. · Journal of Biological Chemistry · 1988 · 472 citations · Full text

Life Sciences, Immunology, Enzymology +11

Human macrophages convert <scp>l</scp>-tryptophan into the neurotoxin quinolinic acid

Melvyn P. Heyes, Kuniaki Saito, Sanford P. Markey · Biochemical Journal · 1992 · 448 citations · Full text

Life Sciences, Neurobiology, Neuroscience +12

Brain glia release factors with opposing actions upon neuronal survival

Dana Giulian, K Vaca, M Corpuz · Journal of Neuroscience · 1993 · 434 citations · Full text

Medicine, Neurobiology, Neuroscience +17

Monokine production by microglial cell clones

Marco Righi, Lucia Mori, Gennaro De Libero et al. · European Journal of Immunology · 1989 · 377 citations

Life Sciences, Neurobiology, Neuroscience +12