THE USE OF VERODIGEN (A DIGITALIS GLUCOSIDE) IN CARDIOVASCULAR DISEASE, ITS BIOLOGICAL ASSAY, AND PHARMACOLOGICAL ACTION

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Article1 December 1934THE USE OF VERODIGEN (A DIGITALIS GLUCOSIDE) IN CARDIOVASCULAR DISEASE, ITS BIOLOGICAL ASSAY, AND PHARMACOLOGICAL ACTIONW. D. STROUD, F.A.C.P., A. E. LIVINGSTON, A. W. BROMER, J. B. VANDERVEER, G. C. GRIFFITHW. D. STROUD, F.A.C.P., A. E. LIVINGSTON, A. W. BROMER, J. B. VANDERVEER, G. C. GRIFFITHAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-8-6-710 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONThose who have assayed digitalis by any of the recognized biological methods are well aware of the difficulties encountered, and those who prescribe assayed products are frequently confronted with uncertain results. Consequently, any stable digitalis preparation producing the desired therapeutic effects and at the same time being sufficiently uniform in its action not to require a biological assay, would be greatly appreciated. From the long list of digitalis preparations on the market it is evident that no such ideal substance is available at the present time.According to many reports, verodigen has been used in Europe for a number...Bibliography1. STRAUBKREHL WL: Über Verodigen (Gitalin), Deutsch. Med. Wchnschr., 1919, xlv, 281-283. CrossrefGoogle Scholar2. KRAFT F: Die Glykoside des Blätter der Digitalis purpurea , Arch. d. Pharm., 1912, ccl, 118-141. CrossrefGoogle Scholar3. SCHMIEDEBERG O: Untersuchungen über die pharmakologisch wirksamen Bestandtheile der Digitalis purpurea, L., Arch. f. exper. Path. u. Pharmakol., 1874-75, iii, 16. CrossrefGoogle Scholar4. MANSFELDHORN GZ: Untersuchungen über die Wirkungsweise des Gitalins, Arch. f. exper. Path. u. Pharmakol., 1929, cxliv, 46-54. CrossrefGoogle Scholar5. BURN JH: Methods of biological assay, 1928, Oxford University Press. Google Scholar6. STROUDBROMERGALLAGHERVANDERVEER WDAWJRJB: A clinical comparison of a purified glucoside and whole leaf preparations of digitalis, Am. Jr. Med. Sci., 1934, clxxxvii, 746. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: W. D. STROUD, F.A.C.P.; A. E. LIVINGSTON; A. W. BROMER; J. B. VANDERVEER; G. C. GRIFFITHAffiliations: Philadelphia, Pennsylvania*Read at the Chicago meeting of the American College of Physicians, April 19, 1934.From the Robinette Foundation and the Graduate Hospital of the University of Pennsylvania, in part under the Morris W. Stroud Jr. Fellowship in Cardiology; and from the Department of Pharmacology of Temple Medical School. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDigitalis assayGitalin studiesTherapeutic and Toxic Indexes of DigitalisAbsorption of orally administered cardiac glycosides in catsThe Clinical Use of Digitalis PreparationsCLINICAL EVALUATION OF GITALIN IN THE TREATMENT OF CONGESTIVE HEART FAILURE*SIM P. DIMITROFF, M.D., GEORGE C. GRIFFITH, M.D., M. C. THORNER, M.D., JOSEPH WALKER, M.D.Studies with intravenous gitalin. IStudies with gitalin (amorphous) for the treatment of patients with congestive heart failureThe Choice and Method of Administration of Digitalis Glycoside PreparationsClinical studies on digoxin, a purified digitalis glycosideClinical studies of gitalin and of digitalis in the treatment of auricular fibrillationFurther Pigeon Bioassays and Diuretic Tests of Digitaloids**Presented before the Society for Experimental Biology and Medicine, Pacific Coast Branch, San Francisco, February 5, 1936. 1 December 1934Volume 8, Issue 6 Page: 710-726 Keywords Cardiovascular diseases Fellowships Graduate medical education Pharmacology ePublished: 1 December 2008 Issue Published: 1 December 1934 PDF downloadLoading ...