PubMed · 1988 · 38 citations · 0 references
Health ProfessionsOphthalmologyOptometryOcular Drug DeliveryOcular PharmacologyOphthalmic Drug DeliveryCorneal AnatomyCorneal ImagingCorneal PhysiologyOcular Penetration EnhancementOcular Surface AssessmentOcular Surface ImagingAnesthetic Ophthalmic AgentsCorneal Epithelial StainingCorneal Fluorescein ImagingFluorescein Staining ImagingOcular Surface Fluorescence ImagingTopical Anesthetic AgentsTopical Anesthetics In OphthalmologyTopical Ocular Anesthesia
The ocular surface of 74 subjects was assessed with the biomicroscope after sequential instillations of fluorescein (SSI) and again after a single instillation of Ophthetic that was followed by sequential instillations of fluorescein (SSII). Twenty-six eyes (17.6%) stained after SSI and 89 eyes (60%) stained after SSII. The use of Ophthetic seems to enhance the nonuniform penetration of fluorescein into the epithelium in specific regions of the cornea of some subjects. The clinical significance of this finding is unknown.