Synthesis of some antifungal and anti-tubercular 1, 2, 4-triazole analogues.

Abstract

Reaction of 3-(3'-pyridyl)-1, 2, 4-triazole-5-thiol (2) with appropriately N-substituted-α–chloroacetanilides (3a3l) in aq. potassium hydroxide yielded corresponding 5-(N-substituted carboxamidomethylthio)–3-(3'-pyridyl) 1, 2, 4triazoles (4a-4l). Structure of these compounds was established by means of elemental analysis and spectral data. These compounds were subjected to antifungal and anti-TB activities. Anti-fungal activity was carried out against C. albicans and A. niger at the concentrations of 50 and 100 μg/mL using Fluconazole as the standard and in-vitro anti-tubercular activity was done at 50 μg/mL against Mycobacterium tuberculosis H37 Rv.