Prior ibuprofen exposure does not augment opioid drug potency or modify opioid requirements for pain inhibition in total hip surgery

Inhibition of Morphine Tolerance and Dependence by the NMDA Receptor Antagonist MK-801

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Hyperalgesia Mediated by Spinal Glutamate or Substance P Receptor Blocked by Spinal Cyclooxygenase Inhibition

Annika B. Malmberg, Tony L. Yaksh · Science · 1992 · 720 citations

Medicine, Pharmacology, Pharmacotherapy +17

Intrathecal morphine inhibits substance P release from mammalian spinal cord in vivo

Tony L. Yaksh, Thomas M. Jessell, R. Gamse et al. · Nature · 1980 · 697 citations

Medicine, Neuroscience, Pharmacology +12

Incidence and Risk Factors for Side Effects of Spinal Anesthesia

Randall L. Carpenter, Robert A. Caplan, David Brown et al. · Anesthesiology · 1992 · 635 citations · Full text

Veterinary Medicine, Anesthesiology, Anesthesia +15

Thermal hyperalgesia in association with the development of morphine tolerance in rats: roles of excitatory amino acid receptors and protein kinase C

J Mao, D.J. Mayer · Journal of Neuroscience · 1994 · 455 citations · Full text

Medicine, Neuroscience, Pharmacology +17