Expedient and Divergent Tandem One-Pot Synthesis of Benz[<i>e</i>]indole and Spiro[indene-1,3′-pyrrole] Derivatives from Alkyne-Tethered Chalcones/Cinnamates and TosMIC

Abstract

An efficient solvent-dependent regioselective [3 + 2]-cycloaddition/iodocyclization cascade reaction of alkyne-tethered chalcones/cinnamates and TosMIC has been developed. The reaction represents a novel protocol for the expedient and divergent one-pot synthesis of benz[e]indoles and spiro[indene-1,3'-pyrroles] from acyclic common precursors at room temperature.