Influence of an anti-tumor necrosis factor monoclonal antibody on cytokine levels in patients with sepsis - Concepedia

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Influence of an anti-tumor necrosis factor monoclonal antibody on cytokine levels in patients with sepsis

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References

1993

Year

Charles J. Fisher, Steven M. Opal, Jean-François Dhainaut, Sue Stephens, Janice L. Zimmerman, Peter Nightingale, S. Harris, Roland M.H. Schein, Edward A. Panacek, Jean‐Louis Vincent,

Critical Care Medicine

Abstract

The murine anti-TNF-alpha monoclonal antibody CB0006 has proven to be safe in this clinical trial and may prove to be useful in septic patients with increased circulating TNF concentrations. Further studies are needed to determine efficacy and the ultimate clinical utility of this immunotherapeutic agent in sepsis.