Experimentally Produced Lesions of the Liver

Abstract

Article1 December 1931Experimentally Produced Lesions of the LiverJESSE L. BOLLMAN, M.D., FRANK C. MANN, M.D.JESSE L. BOLLMAN, M.D.Search for more papers by this author, FRANK C. MANN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-5-6-699 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMany problems of clinical medicine have been clarified by experimentation on animals. This method has numerous advantages in that most of the factors which enter into the production and progression of abnormal processes are capable of exact control. Although it is not as yet possible exactly to simulate in animals all of the types and phases of hepatic disorders, it is possible to produce experimentally most of the abnormal conditions usually associated with hepatic disease in human beings. With our associates we have studied a large number of animals following various procedures which have directly affected the liver, and it...References1 BEAVER MG: Cholecystogastrostomy: an experimental study, Arch. Surg., 1929, xviii, 899-912. CrossrefGoogle Scholar2 BOLLMANMANN JLFC: Studies on the physiology of the liver. XVIII. The effect of removal of the liver on the formation of ammonia, Am. Jr. Physiol., 1930, xcii, 92-106. CrossrefGoogle Scholar3 BOLLMANMANN JLFC: Peptic ulcer in experimental obstructive jaundice, Arch. Surg. (In press). Google Scholar4 BOLLMANMANNMAGATH JLFCTB: Studies on the physiology of the liver. VIII. Effect of total removal of the liver on the formation of urea, Am. Jr. Physiol., 1924, lxix, 371-392. XII. Muscle glycogen following total removal of the liver, Am. Jr. Physiol., 1925, lxxiv, 238-248. X. Uric acid following total removal of the liver, Am. Jr. Physiol., 1925, lxxii, 629-646. XV. Effect of total removal of the liver on deaminization, Am. 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Assoc., 1929, xciii, 1193-1199 CrossrefGoogle Scholar20 WILHELMJBOLLMANMANN CMJLFC: Studies on the physiology of the liver. XVII. The effect of removal of the liver on the specific dynamic action of amino acids administeredintravenously, Am. Jr. Physiol, 1928, lxxxvii, 497-509. CrossrefGoogle Scholar21 WILLIAMSONMANN CSFC: Studies on the physiology of the liver. V. The hepatic factor in chloroform and phosphorus poisoning, Am. Jr. Physiol., 1923, lxv, 267-276. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Rochester, Minnesota*Read at the Baltimore Meeting of the American College of Physicians, March 23 to 27, 1931.†From the Division of Experimental Surgery and Pathology, The Mayo Foundation, Rochester, Minnesota. 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